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Brabetz and his co-authors generated PDX-derived 3D organoids retaining genetic and transcriptional heterogeneity of primary tumors that were strategic to demonstrate that group 3 organoids with MYC amplification exhibit invasive growth patterns depending on the 3D extracellular matrix (ECM) (such as collagen) and that venetoclax (a BCL-2 inhibitor) synergizes with chemotherapy, overcoming apoptosis resistance (115, 116)

Cancer Genet 284:3442 Liang D, Minikes AM, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling

Schroeder JW, Vezina LG