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Rather than binding directly to the enzyme active site, copper ions interfere with the enzymes function at concentrations achievable through topical or injectable application

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Co-loading of inhaled corticosteroid (budesonide) and antifibrotic natural product (colchicine) in liposomes and delivery to deep lung tissues as a dry powder using DPI, which can achieve site-specific delivery, reduce systemic exposure and prolong drug residence time in the lung (more than 24 hours), thus synergistically improving fibrotic lesions

doi: 10.1007/s00240-011-0448-9 70 PizzinoGIrreraNCucinottaMPallioGManninoFArcoraciVet al

Smirnov et al., 2014)

Paradoxical neurological deterioration has prompted the discussion whether d-penicillamine should be used in neurological WD patients and led to the search for safer treatments 92,165