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Researchers often investigate safety and tolerability as part of the scientific evaluation process

AEs leading to trial product discontinuation occurred in 6/90 (7%) participants in the CagriSema 2.4 mg/2.4 mg group, 11/93 (12%) participants in the CagriSema 1 mg/1 mg group, and 1/91 (1%) in the placebo group

Another significant obstacle is the permeability of the bloodbrain barrier, as many small compounds that demonstrate strong in vitro efficacy have limited exposure to the central nervous system (CNS) in vivo, necessitating high doses that may increase systemic toxicity

Chehab FF, Lim ME, Lu R

Several studies reported that the levels of MDA in plasma were markedly higher in OA patients than in healthy controls [98,99,100]

Su et al., 2023