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doi: 10.3389/fcimb.2025.1662442 Received 09 July 2025 Accepted 18 August 2025 Published 25 September 2025 Volume 15 - 2025 Edited by Yuanwei Zhang, Nanjing Normal University, China Reviewed by Estela Ruiz-Baca, Jurez University of the State of Durango, Mexico Antonio Vitiello, Ministry of Health, Rome, Italy Hu Pengjie, Chinese Academy of Sciences (CAS), China Updates Copyright 2025 Li, Liu, Jiang, Yang, Ni, Zhang and Tan

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Chaperone cycle of Hsp70 The chaperone cycle is mediated by the N-terminal NBD, which regulates the binding of Hsp70 with substrates through switch of two states

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In support of this, ob/ob mice exhibit markedly decreased 3 -AR expression in adipocytes (Collins et al., 1994), which was associated with decreased catecholamine-stimulated lipolysis
