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Initially, the pathogenesis of NASH was explained by the 2-hit hypothesis, where the first hit, hepatic triglyceride accumulation (steatosis), increases the livers susceptibility to injury from second hits, such as inflammatory cytokines, mitochondrial dysfunction, and oxidative stress [37,38]
Normally sequestered in cytoplasm by Keap1

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AAOS, San Francisco, CA, February 7-11 The Seasonality of Postoperative Infection in Spine Surgery

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doi: 10.1016/0140-6736(93)90882-h
