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Our recent genome-wide ChIP-Seq global study also found that NRF2 directly regulates genes involved in PPP along with focal adhesion pathways in A549 NSCLC cells.61 The genes associated with the focal adhesion pathway can promote glucose consumption, lipogenesis and glutamine dependence, ultimately leading to the promotion of tumor growth.62 To shed light on the metabolic features of NRF2-activated lung cancers, Saigusa et al

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Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells

Neither is definitively bettertheir complementary roles in reducing oxidative stress make them effective allies for health, whether used separately or together, depending on your wellness goals

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