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NAD+ shortage especially affects muscle stem cells, where mitochondrial problems signal stem cell aging, which results in fewer stem cells and less regenerative potential

79 - 81 Furthermore, the observed considerable recovery of the skin wound and muscle, tendon, ligament and bone, after severe injury that could be not spontaneously healed 65 - 81 may be quite indicative

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Nutrients 8(12):E798 Funding This study was supported by a grant of University of Perugia (Fondo di finanziamento della ricerca di base del Dipartimento di Scienze Chirurgiche e Biomediche, year 2015) and registered in ISRCTN number 14115156