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These specific estrogen metabolites increase the risk of breast cancer.[ref] Thus, you dont want certain Phase I metabolites hanging around in the body
Sellos-Moura M, Glavin F, Lapidus D, Evans K, Lew CR, Irwin DE

A novel alpha5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia

doi: 10.1016/j.ultsonch.2025.107494

Other common issues include vomiting, diarrhea, abdominal pain, and constipation

Indeed, reversing glucocorticoid resistance is one of the ways in which many antidepressants work [25]