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Both smokers and passive smokers have lower plasma and leukocyte vitamin C levels than non-smokers [10,210,211], partly due to increased oxidative stress and to both a lower intake and a higher metabolic turnover of vitamin C compared to non-smokers [10,211,212,213]

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The association that developed between the response and the independent elements was modeled using the following second-order polynomial equation: In the statistical model, the dependent variable is represented by Y, the independent variables by X i and X j , and the coefficients for the intercept, linear terms, quadratic terms, and interaction terms are denoted by 0 , i , ii , and ij , respectively

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