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It can inhibit a key step of the folate cycle (at the level of 5-methyltetrahydrofolate), leading to the accumulation of AICAR a natural analog of AMP that potently activates AMPK

Roles of reactive oxygen and nitrogen species in pain

doi: 10.1073/pnas.1424638112
For more on keeping vitamin levels up, even if youre on meds like metformin, check out Mayo Clinics guide to vitamin B12

doi: 10.1046/j.0007-1323.2001.02025.x

We detail their actions in disrupting core metabolic pathways and elucidate their influence on TME components like cancerassociated fibroblasts, extracellular matrix, and immune cells including tumorassociated macrophages and T lymphocytes
