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15 Of note, no medical device should be advertised as FDA approved or cleared. This is considered misbranding by the FDA under section 21 CFR 807.97

All data and materials are available to the researchers once published

However, it is likely that enzymes (PO, NADPH:quinone reductase, NADPH oxidase) and the supply of Cu/Fe ions can direct these conversions in the desired direction

Notably, the origin and fate of acetyl-CoA are key factors that help distinguish between M1 and M2 ( Figure 1 Figure 2 In a nutshell, pro-inflammatory M1 macrophages are metabolically characterized by a high reliance on aerobic glycolysis and present two key breaks in the TCA cycle, leading to the accumulation of citrate, succinate, and itaconate