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No significant changes were found in plasma concentrations of alanine aminotransferase (ALAT), alkaline phosphatase (AP), and creatinine 24 hours after treatment initiation (T24)

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37,38 Sympathetic signaling activates the hypothalamic-pituitary-adrenal (HPA) axis, a network that connects the nervous system to the adrenal glands and controls their release of the bodys primary stress hormone, cortisol