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This increase in sorbitol poses an issue due to its inability to easily pass through the cell membrane, leading to its intracellular accumulation

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In contrast, others found consistently lower sperm DNA fragmentation levels in the postoperative period (e.g., three months), without further significant improvement over time (61, 156)

Conversely, interactions between M1 microglia and A1 astrocytes lead to the production of excitatory amino acids, which trigger the expression of MMPs in ischemic brain regions, compromising BBB integrity

The introduction of a diet high in fat expedited the onset and progression of AS, aligning with existing literature findings

Inhibition of the reninangiotensin system (RAS) and activation of glucagonlike peptide1 (GLP1) receptor signalling may reverse this effect