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Prostaglandins, especially PGE2 and PGI2, are produced continuously via COX by the gastric epithelium and participate in the maintenance of stomach homeostasis and the healing of ulcers by acting by inhibiting gastric acid secretion and increasing mucus and bicarbonate production (Koji and Kikuko, 2018)

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Edmonds M., Manu C., Vas P

Neurosci Lett 2010;480:132-7

Neuropeptides such as substance P (SP), vasoactive intestinal polypeptide (VIP), and acetylcholine (ACh) have all been implicated in increased vascular flow

The discoloration is attributed by community sources to copper localization in the subcutaneous tissue

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