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The reason: since the fragment contains only the C-terminal part, it lacks the binding domains for GHR (most of the affinity of hGH for GHR lies in the central part of the molecule)

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doi: 10.1016/j.bbamcr.2016.09.003

Similar content being viewed by others Main DNA methylation is an epigenetic mark widely studied for its association with diseases such as cancer 1 and autoimmune disorders 2 , with environmental exposures 3 and with other biological phenomena 4,5

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The extracted data included the first author, study characteristics (i.e