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Substituting a D-alanine (the mirror-image stereoisomer) at position 2 makes that bond a poor substrate for the enzyme, because DPP-IVs active site is stereospecific and does not accommodate the D-configuration well
doi: 10.1016/j.ijheh.2011.03.001
E., Morris H
Lenhart et al, 2012)
Biochip J
