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Targeting this is an attractive therapeutic strategy that yielded promising results in animal models of pulmonary and hepatic fibrosis [15, 90] but human trials have not been as positive [15]

Changes from Th2 to Th1 cytokine pattern have been demonstrated to counteract the airway hyperresponsiveness and bronchial inflammation (42)

doi: 10.1007/s00248-013-0326-

Combining multiple models can help overcome individual limitations

[DOI] [PubMed] [Google Scholar] 6.Lee C.E., Zembower T.R., Fotis M.A., Postelnick M.J., Greenberger P.A., Peterson L.R., Noskin G.A

Trials were conducted in the outpatient setting at the University of Chicago