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In fact, in a study from Denmark, there was a trend for a protective effect for the variant (Leu) allele in lung cancer cases compared to controls (296), and, similarly, other studies have found a protective effect for the Leu allele (144, 399)
Epigenetics definition: Gene expression can be dialed up or down through preconception interventions, affecting resilience to stress, glucose metabolism, and detoxification capacity

Activation of these receptors results in some cells (such as epithelial cells or cells of the innate immune system) producing IL-32, a cytokine that activates/differentiates monocytes into macrophages and induces the production of proinflammatory cytokines such as IL-1, IL-6, and TNF by activating NF-B in differentiated macrophages [231,232,233]

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