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Evidence supports the association between UA and predictive biomarkers of AD

Cell 180(4):603604 Suzuki N, Suzuki M, Murakami K, Hamajo K, Tsukamoto T, Shimojo M (2012) Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates

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These findings suggest that the capacity of NAC to maintain extracellular glutamate levels is facilitated by enhancing the negative feedback systems that control glutamate release via mGluR2/3

GPX4 detoxifies phospholipid hydroperoxides to non-toxic phospholipid alcohols using glutathione as a source of reducing equivalents, thus preventing ferroptotic cell death