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Some patients notice improvements in energy or mood within a few weeks, while changes in body composition and libido may take longer

This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates

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doi: 10.1074/jbc.M005159200

TRT is typically recommended for men who have been diagnosed with low testosterone levels and are experiencing symptoms such as fatigue, decreased libido, muscle loss, or cognitive difficulties

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