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Contrary to DNA glycosylases, NER machinery does not have specificity to a base modification per se but rather recognizes a DNA helix distortion, whereas DNA glycosylases are highly specific to the base modifications, because a damaged base should fit into their active site pocket

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[DOI] [PubMed] [Google Scholar] Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ

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