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To work again, it needs to be recycled by another antioxidant

10.1038/s42255-020-0224-7 19 CarlsonB

Moreover, these redox reactions form the basis for the post-translational modulation (PTM) of a wide range of proteins that regulate not only metabolism but also ROS signalling and proteinprotein interactions, such as those of the chloroplast CP12-2/phosphoribulokinase (PRK)/glyceraldehyde 3-phosphate dehydrogenase (GAPB) ternary complex

Chronic kidney disease and acute kidney injury may both elevate levels

As just one example, a recent study demonstrated that, although the neuropathic pain induced by chemotherapeutic agents such as paclitaxel is mediated at the very early stage of its development by activation of the innate immune system, its resolution is actually dependent on the involvement of the adaptive immune system and more specifically the trafficking of CD8+ T cells into the dorsal root ganglia (129)