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This inhibition parallels the effects observed with indomethacin, a conventional COX-2 inhibitor, and underscores BVs capability to attenuate inflammatory mediators within synoviocytes of RA patients ( Melittins mechanism of action extends to the suppression of NF- activity, achieved by inhibiting IB kinases (IKK and IKK ), reducing I phosphorylation, and preventing p50 translocation into the nucleus ( Figure 6 )

Billes SK, Cowley MA

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47 The indirect mechanism involves inhibition of system Xc , the cystine/glutamate antiporter, leading to decreased intracellular levels of cystine and, consequently, cysteine, a precursor of GSH

Synergistic ferroptosis-gemcitabine chemotherapy of the gemcitabine loaded carbonaceous nanozymes to enhance the treatment and magnetic resonance imaging monitoring of pancreatic cancer

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