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Preclinical research suggests it may influence nitric oxide pathways, vascular endothelial growth factor, and cellular survival mechanisms involved in wound healing and tissue regeneration

The agency cited insufficient information about potential harm, immune reaction risks, contamination concerns, and lack of any approved indication

Protein expression Capillary Western Immunoassay was performed on Wes system using 12230 kDa Separation Module according to manufacturers instructions (Protein Simple, USA)

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10.1038/nrneurol.2017.49 Nat Rev Neurol

Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manet J, van Handel B, Ibrahim, S., Greve, J., Mikkola, H., Artavanis-Tsakonas, S., and Aifantis, I., "In vivo mapping of Notch pathway activity in normal and stress hematopoiesis", Cell Stem Cell 13: (2013)