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In addition, PF is also associated with cough and breathing difficulties (Martinez et al., 2017)

Reactive oxygen species signalling in the deterioration of quality of mammalian oocytes cultured in vitro : Protective effect of antioxidants

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The role of betaine in the methylation process becomes more crucial under conditions of folate deficiency such as excessive alcohol consumption that impairs folate metabolism and interferes with folate-dependent methylation [158,159]

Results are maintained with ongoing treatment