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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

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This reaction not only converts toxic oxidants into harmless substances (such as water) but also creates conditions for the subsequent reduction process by storing electrons in disulfide bonds

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[DOI] [PMC free article] [PubMed] [Google Scholar] 163.Wegkamp A., Starrenburg M., de Vos W.M., Hugenholtz J., Sybesma W

A small peptide targeting the ligand-induced androgen receptor/filamin a interaction inhibits the invasive phenotype of prostate cancer cells