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Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms

The addicted person feels an inner compulsion to increase doses of psychoactive substances, losing control over their use

95%CI: 0.90-1.20

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Even though oral treatments of the methyl donor SAM ameliorated ASD-associated deficits in valproic acid (VPA)-exposed mice by reversing epigenetic changes, there has been limited success thus far in the development of preventative agents similar to SAM for the clinical management of ASD in humans