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2 ROS in sensing and reaction to damage 2.1 ROS in infectious inflammation During the initial stage of an inflammatory process, immune cells activated in response to invading pathogens or agents release various inflammatory mediators, aiding in increased vascular permeability and leukocyte migration towards the tissue injury site (12)

Free Rad Biol Med 52:973982 Sanchez M, Galiesto M, Vera R, Villar IC, Zarzuelo A, Tamargo J et al (2006) Quercetin downregulates NADPH oxidase increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats

Since metformin causes changes in blood sugar, The National Institutes of Healths National Library of Medicine notes (11) that its important to know the symptoms of both high and low blood sugar

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