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Mechanism studies showed that p53-induced miR-145a inhibited osteogenesis by targeting core binding factor beta (Cbfb) [140]

Cooper AJL, Hanigan MH (2018) Metabolism of glutathione S-conjugates: multiple pathways

Treatment of AMs with synthetic miR-21-5p mimics or miR-NC revealed that miR-21-5p significantly reduced the intracellular bacterial counts of Actinobacillus pleuropneumoniae (APP) when compared to miR-NC treatment( Figure 4D ) through a novel mechanism: the PIK3CD gene in AMs is targeted to activate the PI3K/Akt pathway, which in turn induces autophagy, this inhibits the overproduction of ROS and activates the NLRP3 inflammasome, preventing focal death and improving bacterial clearance

Nat Rev Immunol (2020) 20:5156

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The finger joints work like hinges when the fingers bend and straighten