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To further validate the role of DT-109 in SMC phenotype conversion, we conducted in vitro experiments using ox-LDL-treated HASMC and A7r5 cells

One mechanism involves reducing transforming growth factor beta-1 secretion in fibroblasts

Intramuscular injection of vitamin B 12 was performed in 4 patients and the oral symptoms improved in all
Centre for Clinical Practice at NICE (UK)

Curtis WM et al

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