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To further test this possibility, we performed a cluster analysis of RNA-seq data from 25 liver cancer cell lines derived from human liver tumors in the Broad Institute Cancer Cell Line Encyclopedia (CCLE) database
Subsequent flow cytometric analysis of NRF2 expression in ILC2s revealed that melatonin treatment significantly increased NRF2 protein levels ( Figure 6D )
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That specific stability claim has not been published in any peer-reviewed journal as of April 2026
However, they are also the major site of reactive oxygen species (ROS) production due to electron leakage during oxidative phosphorylation
