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ERRs are nuclear receptors that sit upstream of mitochondrial biogenesis, fatty acid oxidation, and the aerobic gene program activated by endurance exercise

This potentially hazardous combination of oxygen and iron within the erythrocyte is kept in check by several endogenous mechanisms

HIF-1 overexpression may alleviate OGD/R-induced injury, by suppressing miR-134 expression (Zhang et al., 2020a)

JACC Cardiovasc

Comparing the changes in GPX4/SQSTM1 related proteins with high and low expression of MT1G in GC patients, the trends in GPX4, SLC7A11 and SQSTM1 were consistent with MT1G, while there was no significant correlation between ARNTL and EGLN2 changes and MT1G (Fig

However, when it is out of balance it sets up an inflammatory cascade of cytokines and chemokines