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124 More recently, a Spanish study supported the connection between acetaminophen exposure during pregnancy and autism in the offspring

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Removal of unwanted variation reveals novel patterns of gene expression linked to sleep homeostasis in murine cortex

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[DOI] [PubMed] [Google Scholar] 49.Chen P., Tang H., Zhang Q., Xu L., Zhou W., Hu X., Deng Y., Zhang L

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hospitalization required Maintenance of Remission: Immunomodulators (azathioprine, 6-MP, methotrexate) for steroid-dependent or frequently-relapsing disease Biologic monotherapy or combination therapy (biologic + immunomodulator) for moderate-to-severe disease Step-up or top-down approach based on disease severity, patient risk factors, and prior therapy Biologic Therapy Targets: TNF-: Infliximab (IV), adalimumab (SC), certolizumab pegol (SC) IL-12/23: Ustekinumab (IV induction, SC maintenance) Integrin: Vedolizumab (IV) IL-23: Risankizumab (IV induction, SC maintenance) JAK inhibition: Upadacitinib (oral) Surgical Management Surgery is indicated in approximately 7080% of patients with Crohns disease over their lifetime, per StatPearls

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