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Marcus Conrad, Helmholtz Munich) were maintained in DMEM (Life Technologies) supplemented with 10% (v/v) bovine calf serum (Life Technologies) and 50 U ml 1 of penicillin and streptomycin (Life Technologies)

For example, in one trial, curcumintreated patients showed better UPDRS motor scores compared to placebo (though no change in disease progression markers), and a cocoa intervention (high in flavanols) showed positive trends in reducing fatigue and motor symptoms [78]

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The low CSF-to-plasma ratio of compound D and the absence of compound Q in CSF may suggest the need for Phase Ib dosing studies to explore novel strategies for increasing Q bioavailability and D levels in the CNS

however, only female heterozygous mice were obtained because hemizygous male embryos died

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