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Anaphylaxis following a B12 injection has been documented in medical literature, particularly in patients with a sensitivity to cobalt or cobalamin compounds

Sealed formulation can be expired within 18-36 months of production while once it gets opened
Associations between nutritional factors and excessive daytime sleepiness in older patients with chronic kidney disease

Its all going to increase your antibody response. But for those who can and want to choose, the NIH study offered some insights

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Oral administration at 100150mg to match subcutaneous bioavailability doubles the per-dose cost, which influences protocol design when budget constraints exist
