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In total, 4 -integrin subunits (1, 2, 10 and 11) harbor a collagen-binding I-domain insert and share the 1 subunit

Hendrickx et al., 2018)

Employing melatonin as an immunomodulatory agent therefore may require higher dosages to be effective, for example in murine models, a dose of 10mg/kg is widely used to investigate the anti-inflammatory and tissue-protective actions of melatonin (18, 2931, 70)

Other defense mechanisms Other defense mechanisms include the nuclear factor erythroid 2 related factor 2 (Nrf2)-mediated pathway, the transsulfuration pathway, and the mTOR signaling pathway [81]

Liu D, Liang CH, Huang B, Zhuang X, Cui W, Yang L, Yang Y, Zhang Y, Fu X, Zhang X, Du L, Gu W, Wang X, Yin C, Chai R, Chu B