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Cisplatin exacerbates hair cell damage through a dual mechanism: on the one hand, it activates nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, which prompts ferritin to release free Fe 2+ , generating a large amount of reactive oxygen species (ROS) via the Fenton reaction and inducing a lipid peroxidation chain reaction (Dai et al., 2024)

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10.1158/2159-8290.CD-19-0338 42 LeeJ.YouJ
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