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1990 Sep;47(9):1008-12

Needling opens microchannels that stay open for roughly 15 minutes, so a low-concentration serum applied immediately after needling reaches the dermis instead of sitting on the surface

Formulation and Device Design to Increase Nose to Brain Drug Delivery

In addition to inhibitory effects on the enzymes in TAG hydrolysis, insulin also decreases measurable rates of lipolysis (as indicated by the release of free fatty acids and glycerol from intact cells) by promoting the re-esterification of fatty acids (16)
