glutathione s transferase catalytic mechanism Structure, Mechanism, and Evolution of the Transferases Frontiers | Glutathione S-Transferase P1

J Diabetes Investig 5:621622

NOXs are a group of enzymes that produce reactive ROS, mainly superoxide, as part of the immunological response

10.1038/ejcn.2009.148 Eur J Clin Nutr

Regulation of GPX4 expression includes multiple mechanisms, such as gene transcription and post-translational modification, which significantly affect the level of lipid peroxidation in tissue damage

Excessive APAP metabolism depletes glutathione and increases N-acetyl-p-benzoquinoneimide (NAPQI) levels, leading to oxidative stress, DNA damage, and cell necrosis in the liver, which in turn leads to liver damage

Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems