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Even though some micronutrients, such as Ca, Mg, Fe, folic acid, and Vit D, have been shown by some researchers to exert a protective effect in sleep [14, 15, 33, 34] while K reportedly has the opposite effect [35], our study did not find any associations between these micronutrients and insomnia

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Most interestingly, ageing reduces NMDA-receptor-dependent LTP across the spectrum of cognitive outcomes, whereas increased NMDA-receptor-independent LTP occurs exclusively in high-performing aged rats indicating that a shift to NMDA-receptor-independent pathways for neural plasticity is an adaptive mechanism with better cognitive outcomes in ageing (Figure 1)

Methods 2.1