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Contemporary evidence on the physiological role of reactive oxygen species in human sperm function

[DOI] [PubMed] [Google Scholar] 121.Powell S.R

Stereological and histological studies exhibited that, after busulfan treatment, some large vacuoles were observed in the semi-niferous tubules in the rat testis and the size of seminiferous tubules was reduced, which was linked to disorganization and reduction of height of germinal epithelium following depletion of spermatogenic lineage cells (spermatogonia, spermatocytes, and round elongated spermatid)

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Furthermore, in our effort to shed light on the molecular mechanism underlying ATZs ability to lower serum levels of testosterone, FSH, and LH, we examined the expression of certain genes and discovered that exposure to ATZ significantly downregulated the relative expression levels of 3-HSD , StAR , and CYP11A1 , which may help to explain why exposure to ATZ lowers these hormone levels