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[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Mandl J., Szarka A., Banhegyi G

Large reports have shown natural products have strong therapeutic values in promoting mitochondrial biogenetics and energetics, reducing mitochondrial ROS, enhancing mitophagy, and regulating mitochondrial dynamics (Mu et al., 2020

Interestingly, studies have shown that cross-talk between HER2 and ERK is conducive to the development of drug resistance ( In addition to members of the RTK family, such as HER2, EGFR, and VEGF, some research has shown that IGFR is also associated with tamoxifen resistance

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Administration of NRF2 activator, which would be favorable for reinvigorating anti-tumor immunity and conferring the metabolic liabilities on cancer cells, in combination with inhibitors of glutamate and/or NEAA synthesis may be an effective anti-tumor therapy from the viewpoint of interaction between cancer cells and their microenvironment