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Transcriptomic analysis and qRT-PCR experiments revealed that their combination regulated AD-related pathways and genes more comprehensively, particularly affecting the Neuroactive ligand-receptor interaction and Calcium signaling pathway

In animals, injection of dopamine also induced TTC-like changes in the animal heart [25]

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Because the model inputs use data prior to the approval of Alzheimer's diseasemodifying therapies (lecanemab and donanemab), those drug costs are not included in the initial model outputs

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