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KSS is a severe syndromic variant of CPEO that progresses to multisystemic effects due to large deletions in the mtDNA of unknown cause
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Mutual interactions between mast cells, basophils, eosinophils, and macrophages, and the secreted mediators (cytokines, chemokines, enzymes, and ROS) can damage the epithelium of intestinal villi (185)
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& de Wit, H
"Meta-analysis of the risk factors for urinary tract infection in children"
