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doi: 10.1007/S00253-011-3557-Z 35 ComaV

A series of recent studies implicated sirtuins as potent negative regulators of fibroblast activation and myofibroblast differentiation, and sirtuin dysfunction has been linked to the pathogenesis of SSc and other fibro-inflammatory conditions 28,29,38,39,40,41,42

Key information was extracted from each publication (whenever relevant) on the study question, characteristics of the participants, form of intervention, biomarkers used to diagnose B12 deficiency, clinical tests, outcomes, and key findings

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For laboratory research use only.) Selective NNMT inhibitor with documented IC values in preclinical biochemical assays (pmc.ncbi.nlm.nih.gov) Studied in diet-induced obese (DIO) mouse models for effects on adipose tissue and metabolic markers