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Data availability Data relating to the materials and methods, optimization and control studies, experimental procedures, HPLC spectra, UV-spectra, NMR spectra, and mass spectrometry are available in the Supplementary Information

Inject the full dose slowly and steadily

Although the precise mechanisms underlying the influence of gut microbes on the brain are not yet fully understood, research suggests that metabolites, or metabolite derivatives (volatile organic compounds, VOCs) produced from the gut microbes are capable to distinguish between individuals with mental disorders and those that are healthy

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Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies