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For neuroprotective mitochondria-targeted drugs with several systemic side effects, such as pitavastatin and pentoxifylline, intranasal drug administration could be a promising option to target the CNS using a lower dose that would minimize systemic exposure, thus decreasing the unwanted adverse systemic effects

doi: 10.1021/acs.jafc.3c05243 79 LiJJiaY-cDingY-xBaiJCaoFLiF

AD and MCI brain and plasma display extensive oxidative stress as indexed by protein oxidation, lipid peroxidation, free radical formation, DNA oxidation, and decreased antioxidants

Often referred to as the "master antioxidant," glutathione helps neutralize harmful free radicals, protects cells from damage and supports overall detoxification

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Park B.K., Dear J.W., Antoine D.J