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Description
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(1994) A controlled trial of cyanocobalamin (vitamin B12) in the treatment of winter seasonal affective disorder
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198,200 YOD1 binds to the N domain and cleaves Lys48-linked ubiquitin on substrates, contributing to substrate release from NPL4UFD1 and their entry into p97/VCP
While no formal clinical trials of this specific combination have been publicly reported as of early 2026, the theoretical basis for synergy is compelling based on the distinct yet complementary mechanisms of each compound [5]
