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Presynaptic DORs produce GABAergic LTD at FSI PV-expressing basket cell inputs to pyramidal neurons of CA2, but only short-term depression in CA1 (Piskorowski and Chevaleyre, 2013)

Other helpful therapies for this phenotype include behavior modification (avoidance of straining and pelvic floor clinching behaviors), control of often associated bowel dysfunction, topical heat, and skeletal muscle relaxants (oral administration and off-label transvaginal/transrectal preparations)

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Dowd, K

Proc Natl Acad Sci USA 2003;100:1007310078

BPC 157 has a particular anxiolytic effect on its own (light/dark, shock probe/burying [57], ketamine [59])