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Understanding your genetic variants, diet, and health conditions can help you optimize B6 intake and wellness

10.7554/eLife.85092.sa2 47

Qasem, R

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Downregulation of NNMT-Driven Pathologies NNMT overexpression is associated with: Obesity (by stabilizing fat storage gene expression) Insulin resistance Cancer (via epigenetic silencing of tumor suppressor genes) By inhibiting NNMT, 5-Amino-1MQ counteracts these pathological effects, promoting: Fat loss Improved insulin sensitivity Anti-tumor and anti-aging effects (in preclinical models) In summary, 5-Amino-1MQs mechanism of action centers on blocking NNMT to rebalance NAD+ and SAM levels, thereby enhancing mitochondrial function, supporting epigenetic stability, and modulating metabolism and inflammation

van Abeelen AFM, Elias SG, Roseboom TJ, Bossuyt PMM, van der Schouw TYT, Grobbee DE, Uiterwaal CSPM
